Awọn agbara C22 tun jẹ sooro lati wọ ni awọn ẹya otutu otutu ati awọn agbegbe ohun-ini. Diẹ ninu awọn agbegbe ninu eyiti awọn iyara wọnyi awọn iyara wọnyi resistance jẹ media iṣatunṣe, Ṣiṣe idinku Media, awọn agbegbe kekora, ati awọn agbegbe ati awọn agbegbe SLUFAR. Wọn jẹ sooro lati kọlu nipasẹ awọn kemikali bii awọn kemikali bii nitric acid, chlorine, efin, Organic, Enganic, irawọ, ati bẹbẹ lọ.